Unité de Recherche : Biologie Structurale des Maladies Infectieuses
Institut Pasteur
28 Rue du Docteur Roux
75015 PARIS
Spécialité : Biologie structurale, Virologie
Directeur de l’unité de rattachement : Pablo GUARDADO-CALVO
Responsable de l’équipe de recherche :
Pablo GUARDADO-CALVO
Courriel : pablo.guardado-calvo@pasteur.fr
Tel : 01 40 61 32 53
Composition de l’équipe de recherche
- GUARDADO-CALVO Pablo (CR-HDR)
- MEOLA Annalisa (IR)
5 publications récentes de l’équipe de recherche
Meola A, Vernuccio R, Battini L, Albericio G, Delgado P, Bamford R, Pokorny L, Broutin M, Martínez León A, Gallien S, Gil M, Noriega MA, Guivel-Benhassine F, Porrot F, Postal J, Buchrieser J, Hubert M, Haouz A, Lafaye P, Esteban M, Hub JS, Mahévas M, Chappert P, Mercer J, Garcia-Arriaza J, Schwartz O, Guardado-Calvo P. Structural basis of poxvirus fusion regulation and anti-A16/G9 antibody-mediated neutralization and protection. Cell. 2025 Oct 30;188(22):6266-6282.e18. doi: 10.1016/j.cell.2025.07.040. Epub 2025 Aug 26. PMID: 40865523.
Vernuccio R, Martínez León A, Poojari CS, Buchrieser J, Selverian CN, Jaleta Y, Meola A, Guivel-Benhassine F, Porrot F, Haouz A, Chevreuil M, Raynal B, Mercer J, Simon-Loriere E, Chandran K, Schwartz O, Hub JS, Guardado-Calvo P. Structural insights into tecovirimat antiviral activity and poxvirus resistance. Nat Microbiol. 2025 Mar;10(3):734-748. doi: 10.1038/s41564-025-01936-6. Epub 2025 Feb 12. PMID: 39939832; PMCID: PMC11879855.
Mittler E, Serris A, Esterman ES, Florez C, Polanco LC, O’Brien CM, Slough MM, Tynell J, Gröning R, Sun Y, Abelson DM, Wec AZ, Haslwanter D, Keller M, Ye C, Bakken RR, Jangra RK, Dye JM, Ahlm C, Rappazzo CG, Ulrich RG, Zeitlin L, Geoghegan JC, Bradfute SB, Sidoli S, Forsell MNE, Strandin T, Rey FA, Herbert AS, Walker LM, Chandran K, Guardado-Calvo P. Structural and mechanistic basis of neutralization by a pan-hantavirus protective antibody. Sci Transl Med. 2023 Jun 14;15(700):eadg1855. doi: 10.1126/scitranslmed.adg1855. Epub 2023 Jun 14. PMID: 37315110; PMCID: PMC11721787.
Serris A, Stass R, Bignon EA, Muena NA, Manuguerra JC, Jangra RK, Li S, Chandran K, Tischler ND, Huiskonen JT, Rey FA, Guardado-Calvo P. The Hantavirus Surface Glycoprotein Lattice and Its Fusion Control Mechanism. Cell. 2020 Oct 15;183(2):442-456.e16. doi: 10.1016/j.cell.2020.08.023. Epub 2020 Sep 15. PMID: 32937107; PMCID: PMC7572791.
Yefet R, Battini L, Hubert M, Rakayev K, Guivel-Benhassine F, Rattner N, Porrot F, Abramovitz L, Ostashinsky G, Ben-Shalom N, Postal J, Polonsky K, Ralph-Altman M, Sweed S, Korner T, Friedel N, Hagin D, Sprecher E, Fishelson Z, Kobiler O, Adler-Abramovich L, Schwartz O, Guardado-Calvo P, Freund NT. Potent neutralization by antibodies targeting the MPXV A28 protein. Nat Commun. 2025 Dec 10;16(1):11455. doi: 10.1038/s41467-025-66344-0. PMID: 41372735; PMCID: PMC12748864.