Unité de recherche : CIC1426
Université Paris Cité
Service de Pharmacologie et Investigations Cliniques
Hôpital Saint-Louis
1 rue Claude Vellefaux
75010 Paris
Spécialité : Biologie moléculaire , Pharmacologie , Recherche clinique , Toxicologie, Modélisation moléculaire
Directeur de l’unité de rattachement : JACQZ-AIGRAIN Evelyne
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Responsable de l’équipe de recherche
JACQZ-AIGRAIN Evelyne
Courriel : evelyne.jacqzaigrain@aphp.fr / evelyne.jacqzaigrain@gmail.com
Tél : 01 87 02 31 74
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Composition de l’équipe de recherche
- DE BEAUMAIS Tiphaine (MC)
- JACQZ-AIGRAIN Evelyne (PU-PH, HDR)
- LIV Tiphanie (CR)
- MAHMOUDI Naura (CR)
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5 publications récentes de l’équipe de recherche
Neumann E, Schreeck F, Herberg J, Jacqz Aigrain E, Maitland-van der Zee AH, Pérez-Martínez A, Hawcutt DB, Schaeffeler E, Rane A, de Wildt SN, Schwab M. Br J Clin Pharmacol. How paediatric drug development and use could benefit from OMICs: A c4c expert group white paper.2022 Jan 7. doi: 10.1111/bcp.15216. Online ahead of print.
Hill LF, Clements MN, Turner MA, Donà D, Lutsar I, Jacqz-Aigrain E, Heath PT, Roilides E, Rawcliffe L, Alonso-Diaz C, Baraldi E, Dotta A, Ilmoja ML, Mahaveer A, Metsvaht T, Mitsiakos G, Papaevangelou V, Sarafidis K, Walker AS, Sharland M; NeoVanc Consortium. Optimised versus standard dosing of vancomycin in infants with Gram-positive sepsis (NeoVanc): a multicentre, randomised, open-label, phase 2b, non-inferiority trial. Lancet Child Adolesc Health. 2022;6:49-59. doi: 10.1016/S2352-4642(21)00305-9. Epub 2021 Nov 26.
Drug Safety in Translational Paediatric Research: Practical Points to Consider for Paediatric Safety Profiling and Protocol Development: A Scoping Review. Aurich B, Jacqz-Aigrain E. Pharmaceutics. 2021;13(5):695. doi: 10.3390/pharmaceutics13050695.
Tang BH, Guan Z, Allegaert K, Wu YE, Manolis E, Leroux S, Yao BF, Shi HY, Li X, Huang X, Wang WQ, Shen AD, Wang XL, Wang TY, Kou C, Xu HY, Zhou Y, Zheng Y, Hao GX, Xu BP, Thomson AH, Capparelli EV, Biran V, Simon N, Meibohm B, Lo YL, Marques R, Peris JE, Lutsar I, Saito J, Burggraaf J, Jacqz-Aigrain E, van den Anker J, Zhao W. Drug Clearance in Neonates: A Combination of Population Pharmacokinetic Modelling and Machine Learning Approaches to Improve Individual Prediction. Clin Pharmacokinet. 2021 Nov;60(11):1435-1448. doi: 10.1007/s40262-021-01033-x. Epub 2021 May 27.
Leroux S, Biran V, van den Anker J, Gotta V, Zhao W, Zhang D, Jacqz-Aigrain E, Pfister M. Serum Creatinine and Serum Cystatin C are Both Relevant Renal Markers to Estimate Vancomycin Clearance in Critically Ill Neonates. Frontiers in Pharmacology.2021;12:634686.doi:10.3389/fphar.2021.634686 eCollection PMID: 33967770
D’Agate S, Musuamba MT, Jacqz-Aigrain E, Della Pasqua O. Simplified dosing regimens for gentamicin in neonatal sepsis. Front Pharmacol. 2021;12:624662. doi: 10.3389/fphar.2021.624662. eCollection 2021. PMID: 33762945
Leroux S, Mechinaud-Heloury F, Jacqz-Aigrain E. Contribution of population pharmacokinetics of glycopeptides and antifungals to dosage adaptation in paediatric onco-hematological malignancies: a review. Frontiers in Pharmacology. 2021 In press