BIS, Bio-Informatique Structurale
Institut Pasteur
DBSC Département de Biologie Structurale et Chimie
25-28 rue du Dr. Roux
75015 Paris
Spécialité : Interface chimie-biologie, Transport membranaire, Modélisation moléculaire, Biologie structurale, Approche in silico, Bioinformatique structurelle.
Directeur de l’unité de rattachement : Paola ARIMONDO
Responsable de l’équipe de recherche
NILGES Michael
Courriel :michael.nilges@pasteur.fr
Tél. : 01 45 68 82 30
Composition de l’équipe de recherche :
- NILGES Michael (PR,HDR)
- BLONDEL Arnaud (CR, HDR)
- BOUVIER Guillaume (CR)
- CHAU Pak-Lee (CR)
- SPERANDIO Olivier (CR, HDR)
- DUCLERT-SAVATIER Nathalie (IR)
5 publications récentes de l’équipe
Mallet V, Checa Ruano L, Moine Franel A, Nilges M, Druart K, Bouvier G, Sperandio O. InDeep: 3D fully convolutional neural networks to assist in silico drug design on protein-protein interactions. Bioinformatics. 2022 Feb 7;38(5):1261-1268. doi: 10.1093/bioinformatics/btab849. PMID: 34908131; PMCID: PMC8826379.
Torchet R, Druart K, Ruano LC, Moine-Franel A, Borges H, Doppelt-Azeroual O, Brancotte B, Mareuil F, Nilges M, Ménager H, Sperandio O. The iPPI-DB initiative: a community-centered database of protein-protein interaction modulators. Bioinformatics. 2021 Apr 9;37(1):89-96. doi: 10.1093/bioinformatics/btaa1091. PMID: 33416858; PMCID: PMC8034526.
Chen, K., Y., Krischuns, T., Ortega Varga, L., Harigua-Souiai, E., Paisant, S., Zettor, A., Chiaravalli, J., Courtney, D., O’Brien, A., Baker, S. C., Isel, C., Agou, F., Jacob, Y., Blondel, A. and Naffakh, N. (2022) “A highly sensitive cell-based luciferase assay for high-throughput automated screening of SARS-CoV-2 nsp5/3CLpro inhibitors” Antivir. Res., (2021), 105272. Doi: 10.1016/j.antiviral.2022.105272, PMID: 35278581, pasteur-03840856v1.
Temmam S, Vongphayloth K, Baquero E, Munier S, Bonomi M, Regnault B, Douangboubpha B, Karami Y, Chrétien D, Sanamxay D, Xayaphet V, Paphaphanh P, Lacoste V, Somlor S, Lakeomany K, Phommavanh N, Pérot P, Dehan O, Amara F, Donati F, Bigot T, Nilges M, Rey FA, van der Werf S, Brey PT, Eloit M. Bat coronaviruses related to SARS-CoV-2 and infectious for human cells. Nature. 2022 Apr;604(7905):330-336. doi: 10.1038/s41586-022-04532-4. Epub 2022 Feb 16. Erratum in: Nature. 2022 Jul;607(7920):E19. PMID: 35172323.
Karami Y, López-Castilla A, Ori A, Thomassin JL, Bardiaux B, Malliavin T, Izadi-Pruneyre N, Francetic O, Nilges M. Computational and biochemical analysis of type IV pilus dynamics and stability. Structure. 2021 Dec 2;29(12):1397-1409.e6. doi: 10.1016/j.str.2021.07.008. Epub 2021 Sep 13. PMID: 34520738.