Unité de Recherche : Unité G5 + Biologie Structurale des Maladies Infectieuses
Institut Pasteur
28 Rue du Docteur Roux
75015 PARIS
Spécialité : Biologie structurale,
Directeur de l’unité de rattachement : Pablo GUARDADO-CALVO
Responsable de l’équipe de recherche :
Pablo GUARDADO-CALVO
Courriel : pablo.guardado-calvo@pasteur.fr
Tel : 01 40 61 32 53
Composition de l’équipe de recherche
- GUARDADO-CALVO Pablo (CR-HDR)
- MEOLA Annalisa (IR)
5 publications récentes de l’équipe de recherche
Serris A, Stass R, Bignon EA, Muena NA, Manuguerra JC, Jangra RK, Li S, Chandran K, Tischler ND, Huiskonen JT, Rey FA#, Guardado-Calvo P#. The Hantavirus Surface Glycoprotein Lattice and Its Fusion Control Mechanism. Cell (2020) PMID: 32937107
Guardado-Calvo P#, Atkovska K, Jeffers SA, Grau N, Backovic M, Pérez-Vargas J, de Boer SM, Tortorici MA, Pehau-Arnaudet G, Lepault J, England P, Rottier PJ, Bosch BJ, Hub JS, Rey FA#. A glycerophospholipid-specific pocket in the RVFV class II fusion protein drives target membrane insertion. Science (2017) PMID: 29097548.
Guardado-Calvo P, Bignon EA, Stettner E, Jeffers SA, Pérez-Vargas J, Pehau- Arnaudet G, Tortorici MA, Jestin JL, England P, Tischler ND, Rey FA. Mechanistic Insight into Bunyavirus-Induced Membrane Fusion from Structure-Function Analyses of the Hantavirus Envelope Glycoprotein Gc. PLoS Pathog (2016) PMID: 27783711
Rouvinski A*, Guardado-Calvo P*, Barba-Spaeth G, Duquerroy S, Vaney MC, Kikuti CM, Navarro Sanchez ME, Dejnirattisai W, Wongwiwat W, Haouz A, Girard-Blanc C, Petres S, Shepard WE, Desprès P, Arenzana-Seisdedos F, Dussart P, Mongkolsapaya J, Screaton GR, Rey FA. Recognition determinants of broadly neutralizing human antibodies against dengue viruses. Nature (2015) PMID: 25581790.
Rouvinski A*, Dejnirattisai W*, Guardado-Calvo P*, Vaney MC, Sharma A, Duquerroy S, Supasa P, Wongwiwat W, Haouz A, Barba-Spaeth G, Mongkolsapaya J, Rey FA, Screaton GR. Covalently linked dengue virus envelope glycoprotein dimers reduce exposure of the immunodominant fusion loop epitope. Nat Commun (2017) PMID: 28534525