Unité de recherche : UMR3569
Institut Pasteur – Université Paris Cité
Institut Pasteur
Unité de Virologie Structurale
25 rue du Docteur Roux
75015 Paris
Spécialité : Biologie structurale , Virologie
Directeur de l’unité de rattachement : Félix REY
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Responsable de l’équipe de recherche
REY Félix
Courriel : rey@pasteur.fr
01 45 68 85 63
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Composition de l’équipe de recherche
- BACKOVIC Marija (CR, HDR)
- BARBA-SPAETH Giovanna (DR, HDR)
- BONTEMS François (DR, HDR)
- DUQUERROY Stéphane (MC, HDR)
- FLAMAND Marie (DR, HDR)
- REY Félix (PR, HDR)
- SAUNIER Bertrand (CR, HDR)
- VANEY Marie-Christine (CR)
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5 publications récentes de l’équipe de recherche
Fernandez, F. Bontems, D. Brun, Y. Coquin, C. A. Goverde, B. E. Correia, A. Gessain, F. Buseyne, F. A. Rey, M. Backovic, Structures of the Foamy virus fusion protein reveal an unexpected link with the F protein of paramyxo- and pneumoviruses. Sci Adv 10, eado7035 (2024).
Antonio Santos-Peral, Fabian Luppa, Sebastian Goresch, Elena Nikolova, Magdalena Zaucha, Lisa Lehmann, Frank Dahlstroem, Hadi Karimzadeh, Julia Thorn-Seshold, Elena Winheim, Ev-Marie Schuster, Gerhard Dobler, Michael Hoelscher, Beate M Kümmerer, Stefan Endres, Kilian Schober, Anne B Krug, Michael Pritsch, Giovanna Barba-Spaeth#, Simon Rothenfusser#. Prior flavivirus immunity skews the yellow fever vaccine response to
cross-reactive antibodies with potential to enhance dengue virus infection. Nat. Comm. 2024. Feb 24;15(1):1696. doi: 10.1038/s41467-024-45806-x. PMID: 38402207; PMCID: PMC10894228. HAL:pasteur-04758357
Crampon E, Covernton E, Vaney MC, Dellarole M, Sommer S, Sharma A, Haouz A, England P, Lepault J, Duquerroy S, Rey FA, Barba-Spaeth G. New insight into flavivirus maturation from structure/function studies of the yellow fever virus envelope protein complex. mBio. 2023 Oct 31;14(5):e0070623. doi: 10.1128/mbio.00706-23. Epub 2023 Aug 21. PMID: 37607061; PMCID: PMC10653854. HAL: pasteur-04188597.
Vaney MC, Dellarole M, Duquerroy S, Medits I, Tsouchnikas G, Rouvinski A, England P, Stiasny K, Heinz FX, Rey FA. Evolution and activation mechanism of the flavivirus class II membrane-fusion machinery. Nat Commun. 2022;13(1):3718. Epub 20220628. doi: 10.1038/s41467-022-31111-y. PubMed PMID: 35764616; PMCID: PMC9239988.
Fernandez I, Saunders N, Duquerroy S, Bolland WH, Arbabian A, Baquero E, Blanc C, Lafaye P, Haouz A, Buchrieser J, Schwartz O, Rey FA. Structural basis of TMPRSS2 zymogen activation and recognition by the HKU1 seasonal coronavirus. Cell. 2024;187(16):4246-60 e16. Epub 20240703. doi: 10.1016/j.cell.2024.06.007. PubMed PMID: 38964326.