Unité de recherche : Institut Pasteur
Institut Pasteur
Département de Biologie Structurale et Chimie
25 rue du Docteur Roux
75015 Paris
Spécialité :Chimie , Modélisation moléculaire , Approches in silico,Microbiologie, Bio-informatique structurale, Biologie structurale
Directeur de l’unité de rattachement : Paola ARIMONDO
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Responsable de l’équipe de recherche
NILGES Michaël
Courriel : michael.nilges@pasteur.fr
Tél : 01 45 68 82 30
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Composition de l’équipe de recherche
- BLONDEL Arnaud (CR, HDR)
- BOUVIER Guillaume (CR)
- CHAU Pak-Lee (CR)
- DUCLERT-SAVATIER Nathalie (IR)
- NILGES Michaël (PR, HDR
- SPERANDIO Olivier (CR, HDR)
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5 publications récentes de l’équipe de recherche
Mallet V, Checa Ruano L, Moine Franel A, Nilges M, Druart K, Bouvier G, Sperandio O. InDeep: 3D fully convolutional neural networks to assist in silico drug design on protein-protein interactions. Bioinformatics. 2022 Feb 7;38(5):1261-1268. doi: 10.1093/bioinformatics/btab849. PMID: 34908131; PMCID: PMC8826379.
Torchet R, Druart K, Ruano LC, Moine-Franel A, Borges H, Doppelt-Azeroual O, Brancotte B, Mareuil F, Nilges M, Ménager H, Sperandio O. The iPPI-DB initiative: a community-centered database of protein-protein interaction modulators. Bioinformatics. 2021 Apr 9;37(1):89-96. doi: 10.1093/bioinformatics/btaa1091. PMID: 33416858; PMCID: PMC8034526.
Chen, K., Y., Krischuns, T., Ortega Varga, L., Harigua-Souiai, E., Paisant, S., Zettor, A., Chiaravalli, J., Courtney, D., O’Brien, A., Baker, S. C., Isel, C., Agou, F., Jacob, Y., Blondel, A. and Naffakh, N. (2022) “A highly sensitive cell-based luciferase assay for high-throughput automated screening of SARS-CoV-2 nsp5/3CLpro inhibitors” Antivir. Res., (2021), 105272. Doi: 10.1016/j.antiviral.2022.105272, PMID: 35278581, pasteur-0384085
Temmam S, Vongphayloth K, Baquero E, Munier S, Bonomi M, Regnault B, Douangboubpha B, Karami Y, Chrétien D, Sanamxay D, Xayaphet V, Paphaphanh P, Lacoste V, Somlor S, Lakeomany K, Phommavanh N, Pérot P, Dehan O, Amara F, Donati F, Bigot T, Nilges M, Rey FA, van der Werf S, Brey PT, Eloit M. Bat coronaviruses related to SARS-CoV-2 and infectious for human cells. Nature. 2022 Apr;604(7905):330-336. doi: 10.1038/s41586-022-04532-4. Epub 2022 Feb 16. Erratum in: Nature. 2022 Jul;607(7920):E19. PMID: 35172323.
Karami Y, López-Castilla A, Ori A, Thomassin JL, Bardiaux B, Malliavin T, Izadi-Pruneyre N, Francetic O, Nilges M. Computational and biochemical analysis of type IV pilus dynamics and stability. Structure. 2021 Dec 2;29(12):1397-1409.e6. doi: 10.1016/j.str.2021.07.008. Epub 2021 Sep 13. PMID: 34520738.
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