Unité de recherche :UMR-3523
Institut Pasteur – Université Paris Cité
Institut Pasteur
Unité de Chimie des Biomolécules
28, rue du Dr Roux
75724 Paris cedex 15
Spécialité : Chimie , Chimie organique, Interface chimie-biologie , Médicament , Recherche clinique , Méthodes analytiques
Directrice de l’unité de rattachement : Paola ARIMONDO
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Responsable de l’équipe de recherche
MULARD Laurence
Courriel : laurence.mulard@pasteur.fr
01 40 61 38 20
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Composition de l’équipe de recherche
- BAY Sylvie (CR)
- BOUCHET Marion (IR)
- COIC Yves-Marie (IR)
- CORNIL Johan (IR)
- MULARD Laurence (DR, HDR)
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5 publications récentes et significatives de l’équipe de recherche
Hu, Z.#; Benkoulouche, M.#; Barel, L-A.#; Le Heiget, G.; Ben Imeddourene, A.; Le Guen, Y.; Monties, N.; Guerreiro, C.; Remaud-Siméon, M.; Moulis, C.; André, I.*; Mulard, L. A.*, A convergent chemoenzymatic strategy to deliver a diversity of Shigella flexneri serotype-specific O-antigen segments from a unique lightly protected tetrasaccharide core. J Org Chem 2021, 86, 2058-75. doi:10.1021/acs.joc.0c00777.
Cohen, C.; Atsmon, J.; Artaud, C.; Meron-Sudai, S.; Gougeon, M. L.; Bialik, A.; Goren, S.; Asato, V.; Ariel-Cohen, O.; Reizis, A.; Dorman, A.; Hoitink, C. W. G.; Westdijk, J.; Ashkenazi, S.; Sansonetti, P. J.; Mulard, L. A.$; Phalipon, A.$, Safety and immunogenicity of a synthetic carbohydrate conjugate vaccine against Shigella flexneri 2a in healthy adult volunteers: a phase 1, dose escalating, single-blind, randomised, placebo-controlled study. Lancet Infect Dis 2021, 21, 546-58. doi: 1016/S1473-3099(20)30488-6.
Dhara, D.; Mulard L. A., Exploratory N-protecting group manipulation for the total synthesis of zwitterionic Shigella sonnei Chem Eur J 2021, 27, 5694-711. doi: 10.1002/chem.202003480.
Cornil, J.#; Hu, Z. Y.#; Bouchet, M.; Mulard, L. A., Multigram synthesis of an orthogonally-protected pentasaccharide for use as a glycan precursor in a Shigella flexneri 3a conjugate vaccine: application to a ready-for-conjugation decasaccharide. Org Chem Front 2021, 8, 6279-99. doi: 10.1039/d1qo00761k.
Phalipon, A.; Mulard L. A., Toward a multivalent synthetic oligosaccharide-based conjugate vaccine against Shigella: state-of-the art for a monovalent prototype and challenges. Vaccines 2022, 10, 403. doi: 10.13390/vaccines10030403.* Co-corresponding authors, # Co-first authors, $ Co-senior authors