Unité de recherche : UMR_S 1124-INSERM
Université Paris Cité
Faculté des Sciences Fondamentales et Biomédicales
Toxicologie Environnementale, Cibles thérapeutiques, Signalisation cellulaire et Biomarqueurs
45 rue des Saints Pères
75270 Paris cedex 06
Spécialité : Biologie cellulaire , Biologie moléculaire , Neurosciences , Pharmacologie
Directeur de l’unité de rattachement : Robert BAROUKI
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Responsable de l’équipe de recherche
MASSAAD Charbel
Courriel : charbel.massaad@u-paris.fr
Tél : 06 64 33 64 17
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Composition de l’équipe de recherche :
- BECKER Christel (PR, HDR)
- BENOLIEL Jean-Jacques (MCU-PH, HDR)
- BERNARD Sophie (PR, HDR)
- BROUILLARD Franck (MC)
- GRENIER Julien (MC)
- JAFARIAN-TEHRANI Mehrnaz (PR, HDR)
- LE MENUET Damien (CR, HDR)
- MASSAAD Charbel (PR, HDR)
- MEFFRE Delphine (MC, HDR)
- SALMON Hugo (MC)
- SIMON Anne (IR)
- THIBAUT Florence (PU-PH, HDR)
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5 publications récentes et significatives de l’équipe de recherche
Targeting the NADPH Oxidase-4 and Liver X Receptor Pathway Preserves Schwann Cell Integrity in Diabetic Mice. Eid SA, El Massry M, Hichor M, Haddad M, Grenier J, Dia B, Barakat R, Boutary S, Chanal J, Aractingi S, Wiesel P, Szyndralewiez C, Azar ST, Boitard C, Zaatari G, Eid AA, Massaad C. 2020 Mar;69(3):448-464. doi: 10.2337/db19-0517. Epub 2019 Dec
Involvement of Aryl hydrocarbon receptor in myelination and in human nerve sheath tumorigenesis. Shackleford G, Sampathkumar NK, Hichor M, Weill L, Meffre D, Juricek L, Laurendeau I, Chevallier A, Ortonne N, Larousserie F, Herbin M, Bièche I, Coumoul X, Beraneck M, Baulieu EE, Charbonnier F, Pasmant E, Massaad C. Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):E1319-E1328. doi: 10.1073/pnas.1715999115.
Mechanical stretch of high Magnitude provokes axonal injury, elongation of paranodal junctions, and signaling alterations in Oligodendrocytes. Chierto E, Simon A, Castoldi F, Meffre D, Cristinziano G, Sapone F, Carrete A, Borderie D, Etienne F, Rannou F, Morrison B 3rd, Massaad C, Jafarian-Tehrani M. Mol Neurobiol. 2018 Oct 8. doi: 10.1007/s12035-018-1372-6.
Targeting demyelination via α-secretases promoting sAPPα release to enhance remyelination in central nervous system. Llufriu-Dabén G, Carrete A, Chierto E, Mailleux J, Camand E, Simon A, Vanmierlo T, Rose C, Allinquant B, Hendriks JJA, Massaad C, Meffre D, Jafarian-Tehrani M. Neurobiol Dis. 2018 Jan;109(Pt A):11-24. doi: 10.1016/j.nbd.2017.09.008.
Nrf2-dependent persistent oxidative stress results in stress-induced vulnerability to depression. Bouvier E, Brouillard F, Molet J, Claverie D, Cabungcal JH, Cresto N, Doligez N, Rivat C, Do KQ, Bernard C, Benoliel JJ, Becker C. Mol Psychiatry. 2017 Dec;22(12):1795. doi: 10.1038/mp.2016.211.