Ralf JOCKERS
Pharmacologie fonctionnelle et Physiopathologie des Récepteurs Membranaires
Unité de recherche : UMR_S1016 – UMR8104 –
Université Paris Cité
Institut Cochin
Université de Paris
22 Rue Méchain
75014 Paris
Spécialité : Biochimie, Biologie cellulaire, Biologie moléculaire, Médicament, Pharmacologie, Modélisation moléculaire
Directrice de l’unité de rattachement : Florence NIEDERGANG
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Responsable de l’équipe de recherche
JOCKERS Ralf
Courriel : ralf.jockers@inserm.fr
Tel: 01 40 51 64 34
DAM Julie
Courriel : julie.dam@u-paris.fr
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Composition de l’équipe de recherche
- DAM Julie (CR, HDR)
- GBAHOU Florence (CR)
- JOCKERS Ralf (DR, HDR)
- MASRI Bernard (CR)
- CECON Erika (CR, HDR)
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5 publications récentes de l’équipe de recherche
Houzé L, Dhenain M, Lam S, Petit F, Haïk S, Mouton-Liger F, Hugon J, Dam J, Paquet C, Jockers R*, Cecon E*. Tau seeding activity in the cerebrospinal fluid of Alzheimer disease patients predicts short-term cognitive decline. Alzheimers Res Ther. 2025 Jul 2;17(1):145. doi: 10.1186/s13195-025-01792-w.
Roca Rivada A, Do Cruzeiro M, Denis R, Zhang Q, Rouault C, Rouillé Y, Launay JM, Cruciani-Guglielmacci C, Mattot V, Clément K, Jockers R, Dam J. Whole-body deletion of Endospanin 1 protects from obesity-associated deleterious metabolic alterations. JCI Insight, 2024 Apr 2;9(9):e168418. doi: 10.1172/jci.insight.168418
Somalo-Barranco G, Pagano Zottola AC, Abdulrahman AO, El Zein RM, Cannich A, Muñoz L, Serra C, Oishi A, Marsicano G, Masri B, Bellocchio L, Llebaria A, Jockers R. Mitochondria-targeted melatonin photorelease supports the presence of melatonin MT1 receptors in mitochondria inhibiting respiration. Cell Chem Biol. 2023 Aug 17;30(8):920-932.e7. doi: 10.1016/j.chembiol.2023.07.009. PMID: 37572668
Gao W, Liu L, Huh E, Gbahou F, Cecon E, Oshima M, Houzé L, Katsonis P, Hegron A, Fan Z, Hou G, Charpentier G, Boissel M, Derhourhi M, Marre M, Balkau B, Froguel P, Scharfmann R, Lichtarge O, Dam J, Bonnefond A, Liu J, Jockers R. Human GLP1R variants affecting GLP1R cell surface expression are associated with impaired glucose control and increased adiposity. Nat Metab. 2023 Oct;5(10):1673-1684. doi:
10.1038/s42255-023-00889-6. Epub 2023 Sep 14. PMID: 37709961
Cecon E, Oishi A, Luka M, Ndiaye-Lobry D, François A, Lescuyer M, Panayi F, Dam J, Machado P, Jockers R. Novel repertoire of tau biosensors to monitor pathological tau transformation and seeding activity in living cells. Elife. 2023 Mar 14;12:e78360. doi: 10.7554/eLife.78360.