Ralf JOCKERS
Pharmacologie fonctionnelle et Physiopathologie des Récepteurs Membranaires
Unité de recherche : UMR_S1016 – UMR8104 –
Université Paris Cité
Institut Cochin
Université de Paris
22 Rue Méchain
75014 Paris
Spécialité : Biochimie , Biologie cellulaire , Biologie moléculaire , Médicament , Pharmacologie , Modélisation moléculaire
Directrice de l’unité de rattachement : Florence NIEDERGANG
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Responsable de l’équipe de recherche
JOCKERS Ralf
Courriel : ralf.jockers@inserm.fr
Tel: 01 40 51 64 34
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Composition de l’équipe de recherche
- DAM Julie (CR, HDR)
- GBAHOU Florence (CR)
- JOCKERS Ralf (DR, HDR)
- LAHUNA Olivier (CR, HDR)
- MASRI Bernard (CR-)
- CECON Erika (CR)
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5 publications récentes de l’équipe de recherche
Somalo-Barranco G, Pagano Zottola AC, Abdulrahman AO, El Zein RM, Cannich A, Mufioz L, Serra C, Oishi A, Marsicano G, Masri B, Bellocchio L, Llebaria A, Jockers R. Mitochondria-targeted melatonin photorelease supports the presence ofmelatonin MTl receptors in mitochondria inhibiting respiration. Cell Chem Biol. 2023 Aug 17;30(8):920-932.e7. doi: 10.1016/j.chembiol.2023.07.009. PMID: 37572668
Gao W, Liu L, Huh E, Gbahou F, Cecon E, Oshima M, Houzé L, Katsonis P, Hegron A, Fan Z, Hou G, Charpentier G, Boissel M, Derhourhi M, Marre M, Balkau B, Froguel P, Scharfinann R, Lichtarge 0, Dam J, Bonnefond A, Liu J, Jockers R. Human GLPlR variants affecting GLP1R cell surface expression are associated with impaired glucose contrai and increased adiposity. Nat Metab. 2023 Oct;5(10): 1673-1684. doi:
10.1038/s42255-023-00889-6. Epub 2023 Sep 14. PMID: 37709961
Cecon E, Oishi A, Luka M, Ndiaye-Lob1y D, François A, Lescuyer M, Panayi F, Dam J, Machado P, Jockers R. Novel repe1toire of tau biosensors to monitor pathological tau transformation and seeding activity in living cells. Elife. 2023 Mar 14;12:e78360. doi: 10.7554/eLife.78360.
Cecon E, Burridge M, Cao L, Carter L, Ravichandran R, Dam J*, Jockers R *. SARS-COV-2 Spike binding to ACE2 in living cells monitored by TR-FRET. Cell Chem Biol. 2021 Jul 2:S2451-9456(21)00307-X. doi: 10.1016/j.chembiol.2021.06.008.
Duquenne M, Folgueira C, Bourouh C, Millet M, Silva A, Clasadonte J, Imbernon M, Fernandois D, MartinezCorral I, Kusumakshi S, Caron E, Rasika S, Deliglia E, Jouy N, Oishi A, Mazzone M, Trinquet E, Tavernier J, Kim YB, O1y S, Jockers R, Schwaninger M, Boehm U, Nogueiras R, Annicotte JS, Gasman S*, Dam J*, Prévot V*. Leptin brain ent1y via a tanycytic LepR-EGFR shuttle contrais lipid metabolism and pancreas function. Nat Metab. 2021 Aug 2. doi: 10.1038/s42255-021-00432-5.