Unité de recherche : UMR8003
Université Paris Cité
Faculté des Sciences Fondamentales et Biomédicales
Saints-Pères Paris
45 Rue des Saints Pères
75006 Paris
Spécialité : Biochimie, Biologie cellulaire , Biologie moléculaire , Modélisation moléculaire, Neurosciences , Pharmacologie , Transport membranaire,
Directeur de l’unité de rattachement : Martin OHEIM
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Responsable de l’équipe de recherche
GASNIER Bruno
Courriel: bruno.gasnier@u-paris.fr
Tél : 06 76 67 04 66
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Composition de l’équipe de recherche
- ACHER Francine (DREM, HDR)
- ANNE-LONGIN Christine (CR, HDR en cours)
- CARREL Damien (MCU, HDR)
- GASNIER Bruno (DR, HDR)
- SAGNE Corinne (C, HDR)
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5 publications récentes et significatives de l’équipe de recherche
Plug-and-socket mechanisms in nutrient sensing by lysosomal amino acid transporters. Gasnier B. Proc. Natl. Acad. Sci. USA (2021) 118, e2102173118 https://doi.org/10.1073/pnas.2102173118
A role for BDNF- and NMDAR-induced lysosomal recruitment of mTORC1 in the regulation of neuronal mTORC1 activity Khamsing D, Lebrun L, Fanget I, Larochette N, Tourain C, de Sars V, Brunstein M, Oheim M, Carrel‡ D, Darchen F, Desnos‡ C (‡ corresponding authors) Mol Brain (2021) 14, 112. https://doi.org/10.1186/s13041-021-00820-8
Arginine-selective modulation of the lysosomal transporter PQLC2 through a gate-tuning mechanism Leray X, Conti R, Li Y, Debacker C, Castelli F, Fenaille F, Zdebik AA, Pusch M, Gasnier B. Proc Natl Acad Sci U S A. (2021) 118, e2025315118 https://doi.org/10.1073/pnas.2025315118 Featured in a PNAS Commentary: PNAS (2021) 118, e2112682118.
Small-Molecule 3D Ligand for RNA Recognition: Tuning Selectivity through Scaffold Hopping Felder S, Sagné C, Benedetti E, Micouin L. ACS Chem Biol (2022) 17, 3069-3076. https://pubs.acs.org/doi/10.1021/acschembio.2c00171
MFSD1 in complex with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes. Jungnickel* KEJ, Guelle* O, Iguchi M, Dong W, Kotov V, Gabriel F, Debacker C, Dairou J, McCort-Tranchepain I, Laqtom NN, Chan SH, Ejima A, Sato K, Massa López D, Saftig P, Mehdipour AR, Abu Remaileh M, Gasnier‡ B, Löw‡ C, Damme‡ M (‡ corresponding authors) Nat. Cell Biol. (2024) 26, 1047-1061; https://doi.org/10.1038/s41556-024-01436-5