Unité de recherche : UMR_S1124
Université Paris Cité
Faculté des Sciences Fondamentales et Biomédicales
HEALTHFEX
45 rue des Saints Pères
75270 Paris cedex 06
Spécialité : Biochimie , Biologie cellulaire , Biologie moléculaire , Environnement , Neurosciences , Toxicologie , Recherche clinique
Directeur de l’unité de rattachement : Xavier COUMOUL
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Responsable de l’équipe de recherche
COUMOUL Xavier
Courriel : xavier.coumoul@u-paris.fr
Tél :06 60 33 74 17
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Composition de l’équipe de recherche
- ANDREAU Karine (MC, HDR)
- BORTOLI Sylvie (IR, HDR)
- CHAUVET Caroline (MC)
- COUMOUL Xavier (PR, HDR)
- KIM Minji (MCU, HDR)
- KOUAL Meriem (MCU-PH, HDR)
- LECURU Fabrice (PU-PH, HDR)
- NOIREZ Philippe (PR, HDR)
- SANQUER Sylvia (PH)
- SEGAL-BENDIRDJIAN Evelyne (DR, HDR)
- SOUSSI Nadia (DR, HDR)
- TETE Arnaud (IR)
- TOMIKIEWICZ Céline (IR)
- YANNICOSTAS Constantin (CR, HDR)
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5 publications récentes et significatives de l’équipe de recherche
Triggering tumorigenic signaling: Succinate dehydrogenase inhibitor (SDHi) fungicides induce oncometabolite accumulation and metabolic shift in human colon cells. Duarte Hospital C, Tête A, Debizet K, Rives C, Imler J, Safi-Stibler S, Gales L, Bellvert F, Dairou J, Hagimont A, Burel A, Lagadic-Gossmann D, Barouki R, Shay JW, Bastin J, Mouillet-Richard S, Lemarié A, Djouadi F, Ellero-Simatos S, Coumoul X, Favier J, Bortoli S.Environ Int. 2025 May;199:109503. doi: 10.1016/j.envint.2025.109503. Epub 2025 May 2.PMID: 40359599
The aryl hydrocarbon receptor: structure, signaling, physiology and pathology. Coumoul X, Barouki R, Esser C, Haarmann-Stemmann T, Lawrence BP, Lehmann J, Moura-Alves P, Murray IA, Opitz CA, Perdew GH, Bourguet W.Signal Transduct Target Ther. 2026 Jan 16;11(1):20. doi: 10.1038/s41392-025-02500-8.PMID: 41540003
A new alternative method using cyp3a65 expression in transgenic zebrafish embryos to assess metabolic endocrine-disrupting chemicals in the intestine. Erradhouani C, Geffroy F, Piccini B, Hinfray N, Chadili E, Balaguer P, Sohm F, Aït-Aïssa S, Coumoul X, Brion F.Environ Int. 2025 Nov;205:109872. doi: 10.1016/j.envint.2025.109872. Epub 2025 Oct 17.PMID: 41151212
Assessment of endocrine disruptor impacts on lipid metabolism in a fatty acid-supplemented HepaRG human hepatic cell line. Bernal K, Touma C, Le-Grand B, Rose S, Degerli S, Genêt V, Lagadic-Gossmann D, Coumoul X, Martin-Chouly C, Langouët S, Blanc EB.Chemosphere. 2024 Feb;349:140883. doi: 10.1016/j.chemosphere.2023.140883. Epub 2023 Dec 11.PMID: 38092172
Organophosphorus diisopropylfluorophosphate (DFP) intoxication in zebrafish larvae causes behavioral defects, neuronal hyperexcitation and neuronal death. Brenet A, Somkhit J, Hassan-Abdi R, Yanicostas C, Romain C, Bar O, Igert A, Saurat D, Taudon N, Dal-Bo G, Nachon F, Dupuis N, Soussi-Yanicostas N.Sci Rep. 2020 Nov 5;10(1):19228. doi: 10.1038/s41598-020-76056-8.