Unité de recherche : UMR8038
Université Paris Cité
Faculté des Sciences Pharmaceutiques et Biologiques
Cibles Thérapeutiques et Conception de Médicaments (CiTCoM)
4 av. de l’Observatoire
75270 Paris Cedex 06
Spécialité : Biochimie, Biologie structurale, Interface chimie-biologie, Microbiologie, Transport membranaire
Directeur de l’unité de rattachement : Nicolas LEULLIOT
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Responsable de l’équipe de recherche
BROUTIN Isabelle
Couriel: isabelle.broutin@u-paris.fr
Tel : 01 53 73 15 77
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Composition de l’équipe de recherche
- AISSAOUI Nesrine (MC)
- BROUTIN Isabelle (DR, HDR)
- DUCRUIX Arnaud (PREM, HDR)
- GAUCHER Jean-François, (MC)
- PHAN Gilles (MC, HDR)
- SALEM Michèle (MC)
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5 publications récentes et significatives de l’équipe de recherche
Wehbi H., Cece Q., Phan G. & Broutin I. (2025) MexB/inhibitor complexes preparation for crystallography and cryo-EM, comparison and possible pitfalls, Methods in Enzymology: Bacterial Efflux Systems, ISSN 0076-6879, https://doi.org/10.1016/bs.mie.2025.08.028, 1-32, https://authors.elsevier.com/a/1lo78HRzCXqIn
Wallart L, Ben Mlouka MA, Saffiedine B, Coquet L, Le H, Hardouin J, Jouenne T, Phan G, Kiefer-Meyer MC, Girard E, Broutin I, Cosette P. (2024) BacA: a possible regulator that contributes to the biofilm formation of Pseudomonas aeruginosa, Front Microbiol., 15:1332448. doi: 10.3389/fmicb.2024.1332448.
Mégret-Cavalier M, Pozza A, Cece Q, Bonneté F, Broutin I, Phan G. (2024) Starting with an Integral Membrane Protein Project for Structural Biology: Production, Purification, Detergent Quantification, and Buffer Optimization-Case Study of the Exporter CntI from Pseudomonas aeruginosa., Methods Mol Biol., 2715:415-430. doi: 10.1007/978-1-0716-3445-5_26.
Aissaoui, N., Mills, A., Lai-Kee-Him, J., Triomphe, N., Cece, Q., Doucet, C., Bonhoure, A., Vidal, M., Ke, Y., and Bellot, G. (2024). Free-Standing DNA Origami Superlattice to Facilitate Cryo-EM Visualization of Membrane Vesicles. J. Am. Chem. Soc. 146, 12925–12932. https://doi.org/10.1021/jacs.3c07328.
Vargiu A.V., Phan G., Venter H., Broutin I. (2022) The Structural and Functional Study of Efflux Pumps Belonging to the RND Transporters Family from Gram-Negative Bacteria, Antibiotics, 11,429, https://doi.org/10.3390/antibiotics11040429